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8 Nights - St. Paul To St. Louis

8-night Upper Mississippi River Cruise

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American Serenade
cruise info

8 Nights - St. Paul To St. Louis

  • American Cruise Lines: American Serenade
  • |
  • September 11, 2026

itinerary

  1. Day 1
    St. Paul
    | Fri Sep 11, 2026
  2. Day 2
    Mississippi River Cruising
    | Sat Sep 12, 2026
  3. Day 3
    La Crosse
    | Sun Sep 13, 2026
  4. Day 4
    River Cruising
    | Mon Sep 14, 2026
  5. Day 5
    Dubuque
    | Tue Sep 15, 2026
  6. Day 6
    Davenport
    | Wed Sep 16, 2026
  7. Day 7
    Hannibal
    | Thu Sep 17, 2026
  8. Day 8
    St. Louis
    | Fri Sep 18, 2026
  9. Day 9
    St. Louis (Alton)
    | Fri Sep 18, 2026
  10. Day 10
    St. Louis (Alton)
    | Sat Sep 19, 2026
  11. Day 11
    St. Louis
    | Sun Sep 20, 2026
Sailing Features
  • 8 Nights
  • Sep 11, 2026 / Sep 19, 2026
  • St. Paul
  • St. Louis
  • American Serenade
  • 11 Land Tours
Bonus Offers
Exclusive Amenities Available:
  • $100 per Couple Shipboard Credit

American Cruise Lines Expert Advisors

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Vicki Keune

(520) 428-7715
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Mary Beth Preston

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Whitney Adams

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American Serenade cruise ship

American Cruise Lines:   American Serenade

American Serenade won Cruise Critic’s Editors’ Picks Award for Best New River Cruise Ship of the Year recently, the first time an American ship has received this prestigious award. Introduces an updated modern interior design, integrating an elegant and refined aesthetic with tradition for the spacious comfort found aboard all of ships Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.
  • Maiden Voyage:
    2023
  • Passenger Capacity:
    175
  • Number of Staterooms:
    91
  • Number of Suites:
    16
  • Wheelchair Accessible:
    Yes
The colorfully painted beach houses of Slovenia as seen from a cave
Don't Miss Out on Any Trip Enhancing Shore Excursions!
Immerse yourself in local culture with authentic cooking classes, traditional dance lessons, and unforgettable visits to historical landmarks during your cruise shore excursions.
A beautiful wooden foyer with luxury seating and shelves filled with fine items
Extend Your Trip with Immersive Pre-Cruise or Post-Cruise Stays
Enjoy the local culture and savor delicious cuisine with pre-cruise or post-cruise stays, ensuring a seamless transition between your land and sea adventures.