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15 Nights - St. Louis To Pittsburgh

15-night Grand Ohio River Cruise

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American Melody
cruise info

15 Nights - St. Louis To Pittsburgh

  • American Cruise Lines: American Melody
  • |
  • June 19, 2026

itinerary

  1. Day 1
    St. Louis
    | Fri Jun 19, 2026
  2. Day 2
    Mississippi River Cruising
    | Sat Jun 20, 2026
  3. Day 3
    Paducah
    | Sun Jun 21, 2026
  4. Day 4
    At Sea
    | Mon Jun 22, 2026
  5. Day 5
    Henderson
    | Tue Jun 23, 2026
  6. Evansville
    | Tue Jun 23, 2026
  7. Day 6
    At Sea
    | Wed Jun 24, 2026
  8. Day 7
    Louisville
    | Thu Jun 25, 2026
  9. Day 8
    Madison
    | Fri Jun 26, 2026
  10. Day 9
    Cincinnati
    | Sat Jun 27, 2026
  11. Day 10
    At Sea
    | Sun Jun 28, 2026
  12. Day 11
    Maysville
    | Mon Jun 29, 2026
  13. Day 12
    At Sea
    | Tue Jun 30, 2026
  14. Day 13
    Marietta
    | Wed Jul 1, 2026
  15. Day 14
    At Sea
    | Thu Jul 2, 2026
  16. Day 15
    Pittsburgh
    | Fri Jul 3, 2026
  17. Day 16
    Pittsburgh
    | Sat Jul 4, 2026
Itinerary map
St. Louis/Pittsburgh
Sailing Features
  • 15 Nights
  • Jun 19, 2026 / Jul 4, 2026
  • St. Louis
  • Pittsburgh
  • American Melody
Bonus Offers
Exclusive Amenities Available:
  • $100 per Couple Shipboard Credit

American Cruise Lines Expert Advisors

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Roni Palacios

(520) 428-7714
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Vicki Keune

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Whitney Adams

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American Melody cruise ship

American Cruise Lines:   American Melody

The Future of American River Cruising™ continues with American Melody, the 4th in the modern riverboat series. American Melody showcases a whole new aesthetic, with an updated interior design, bringing ship to the next level of modern sophistication. Specifically designed to navigate the Mississippi River, American Melody features panoramic views throughout, including an impressive four-story glass atrium in the center of the ship. Ranging from 250 to 650 square feet, all of the spacious staterooms feature full-size bathrooms, roomy closets, and private balconies where you can enjoy daily breakfast room service. American Melody also offers the Ellipse Café for casual dining, an option that has been very popular with the guests.
  • Maiden Voyage:
    2021
  • Registry:
    United States
  • Passenger Capacity:
    175
  • Number of Staterooms:
    91
  • Number of Suites:
    16
  • Dining / Restaurants:
    2
  • Bars / Lounges:
    4
  • Fitness Center:
    Yes

Ship Information

Explore Your Cruise Ship

  • Dining

  • Bar & Lounges

  • Onboard Activities

  • Outdoor Activities

  • Wellness

The colorfully painted beach houses of Slovenia as seen from a cave
Don't Miss Out on Any Trip Enhancing Shore Excursions!
Immerse yourself in local culture with authentic cooking classes, traditional dance lessons, and unforgettable visits to historical landmarks during your cruise shore excursions.
A beautiful wooden foyer with luxury seating and shelves filled with fine items
Extend Your Trip with Immersive Pre-Cruise or Post-Cruise Stays
Enjoy the local culture and savor delicious cuisine with pre-cruise or post-cruise stays, ensuring a seamless transition between your land and sea adventures.