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Cruise the Southeast on American Cruise Line — Huge Cruise & Air Savings

Explore the Southeast by Water with Air and Cruise Savings on Unforgettable American Cruise Line River Escapes Through Historic Coastal Cities and Charming Southern Towns

EXPIRESFeb 28, 2027

Details & Inclusions

Itineraries

Promotion Sailings

  1. Extra Amenities Included
    15-night East Coast Inland Passage Cruise
    Baltimore -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    Oct 26, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  2. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Oct 31, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  3. Extra Amenities Included
    15-night East Coast Inland Passage Cruise
    Baltimore -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Glory

    Departs

    Nov 3, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  4. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Maverick

    Departs

    Nov 3, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  5. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    Nov 9, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  6. Extra Amenities Included
    7-night Gulf Coast Cruise
    New Orleans -> Pensacola

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Nov 10, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  7. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Pioneer

    Departs

    Nov 13, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  8. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Legend

    Departs

    Nov 14, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  9. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Nov 14, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  10. Extra Amenities Included
    7-night Gulf Coast Cruise
    Pensacola -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Nov 16, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  11. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Glory

    Departs

    Nov 17, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  12. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Pioneer

    Departs

    Nov 20, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  13. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Nov 21, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  14. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Dec 12, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  15. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Dec 19, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  16. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Pioneer

    Departs

    Dec 25, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  17. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Ranger

    Departs

    Dec 27, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  18. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    Dec 28, 2026
    Call for Pricing
    (800) 439-7963
    View Details
  19. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Jan 29, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  20. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Glory

    Departs

    Feb 3, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  21. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Feb 5, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  22. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Ranger

    Departs

    Feb 7, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  23. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Legend

    Departs

    Feb 10, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  24. Extra Amenities Included
    7-night Gulf Coast Cruise
    New Orleans -> Pensacola

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Feb 12, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  25. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Ranger

    Departs

    Feb 14, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  26. Extra Amenities Included
    7-night Gulf Coast Cruise
    Pensacola -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Feb 18, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  27. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Glory

    Departs

    Feb 24, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  28. Extra Amenities Included
    7-night Gulf Coast Cruise
    New Orleans -> Pensacola

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Feb 24, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  29. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Feb 26, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  30. Extra Amenities Included
    7-night Gulf Coast Cruise
    Pensacola -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Mar 2, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  31. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Pioneer

    Departs

    Mar 5, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  32. Extra Amenities Included
    7-night Gulf Coast Cruise
    New Orleans -> Pensacola

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Mar 8, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  33. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Mar 12, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  34. Extra Amenities Included
    7-night Gulf Coast Cruise
    Pensacola -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Mar 14, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  35. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Pioneer

    Departs

    Apr 9, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  36. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Apr 16, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  37. Extra Amenities Included
    15-night Grand Florida Coast & Keys Cruise
    Tampa -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Maverick

    Departs

    Apr 20, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  38. Extra Amenities Included
    15-night East Coast Inland Passage Cruise
    Amelia Island -> Washington D.C.

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Glory

    Departs

    Apr 28, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  39. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Pioneer

    Departs

    Apr 30, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  40. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    Oct 29, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  41. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Mariner

    Departs

    Nov 9, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  42. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    Nov 19, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  43. Extra Amenities Included
    7-night Gulf Coast Cruise
    New Orleans -> Pensacola

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Dec 10, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  44. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Dec 12, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  45. Extra Amenities Included
    7-night Gulf Coast Cruise
    Pensacola -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Dec 16, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  46. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    Dec 19, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  47. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Dec 19, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  48. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Legend

    Departs

    Dec 20, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  49. Extra Amenities Included
    7-night Gulf Coast Cruise
    New Orleans -> Pensacola

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Dec 22, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  50. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Legend

    Departs

    Dec 27, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  51. Extra Amenities Included
    7-night Gulf Coast Cruise
    Pensacola -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Dec 28, 2027
    Call for Pricing
    (800) 439-7963
    View Details
  52. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Glory

    Departs

    Feb 18, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  53. Extra Amenities Included
    7-night Gulf Coast Cruise
    New Orleans -> Pensacola

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Feb 20, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  54. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Glory

    Departs

    Feb 25, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  55. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Maverick

    Departs

    Feb 27, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  56. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Navigator

    Departs

    Mar 3, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  57. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    Mar 24, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  58. Extra Amenities Included
    7-night Gulf Coast Cruise
    New Orleans -> Pensacola

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Mar 27, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  59. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Mar 31, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  60. Extra Amenities Included
    15-night Grand Florida Coast & Keys Cruise
    Tampa -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Navigator

    Departs

    Apr 7, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  61. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Apr 7, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  62. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    Apr 14, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  63. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Amelia Island -> Charleston, SC

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    Apr 14, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  64. Extra Amenities Included
    8-night Florida Gulf Coast & Keys Cruise
    Tampa -> St. Petersburg, FL

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Maverick

    Departs

    Apr 23, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  65. Extra Amenities Included
    8-night Southeast Sea Islands Cruise
    Charleston, SC -> Amelia Island

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Liberty

    Departs

    May 12, 2028
    Call for Pricing
    (800) 439-7963
    View Details
  66. Extra Amenities Included
    8-night Great Rivers of Florida Cruise
    Jacksonville -> Jacksonville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Eagle

    Departs

    May 12, 2028
    Call for Pricing
    (800) 439-7963
    View Details

Terms & Conditions

New bookings only. Other restrictions apply. Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time of booking and may be pulled without notice. Pricing may already reflect savings and no further savings will apply. Savings is off cruise fare only; all other charges, including but not limited to, cruise taxes, fees and port expenses are additional and apply to all guests. Information and pricing is subject to change without notice. Not all promotions/sales are combinable. Other restrictions apply. Contact us for details.