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15 Nights - Pittsburgh To St. Louis

15-night Grand Ohio River Cruise

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American Melody
cruise info

15 Nights - Pittsburgh To St. Louis

  • American Cruise Lines: American Melody
  • |
  • July 31, 2026

itinerary

  1. Day 1
    Pittsburgh
    | Fri Jul 31, 2026
  2. Day 2
    Pittsburgh
    | Sat Aug 1, 2026
  3. Day 3
    River Cruising
    | Sun Aug 2, 2026
  4. Day 4
    Marietta
    | Mon Aug 3, 2026
  5. Day 5
    River Cruising
    | Tue Aug 4, 2026
  6. Day 6
    Maysville
    | Wed Aug 5, 2026
  7. Day 7
    Cincinnati
    | Thu Aug 6, 2026
  8. Day 8
    Madison
    | Fri Aug 7, 2026
  9. Day 9
    Louisville
    | Sat Aug 8, 2026
  10. Day 10
    River Cruising
    | Sun Aug 9, 2026
  11. Day 11
    Henderson
    | Mon Aug 10, 2026
  12. Evansville
    | Mon Aug 10, 2026
  13. Day 12
    River Cruising
    | Tue Aug 11, 2026
  14. Day 13
    Paducah
    | Wed Aug 12, 2026
  15. Day 14
    River Cruising
    | Thu Aug 13, 2026
  16. Day 15
    St. Louis
    | Fri Aug 14, 2026
  17. Day 16
    St. Louis
    | Sat Aug 15, 2026
Itinerary map
Pittsburgh/St. Louis
Sailing Features
  • 15 Nights
  • Jul 31, 2026 / Aug 15, 2026
  • Pittsburgh
  • St. Louis
  • American Melody
Bonus Offers
Exclusive Amenities Available:
  • $100 per Couple Shipboard Credit

American Cruise Lines Expert Advisors

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Kimo Dejon

(541) 480-8586
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Mary Beth Preston

(623) 219-4190
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Thea Lawrence

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American Melody cruise ship

American Cruise Lines:   American Melody

The Future of American River Cruising™ continues with American Melody, the 4th in the modern riverboat series. American Melody showcases a whole new aesthetic, with an updated interior design, bringing ship to the next level of modern sophistication. Specifically designed to navigate the Mississippi River, American Melody features panoramic views throughout, including an impressive four-story glass atrium in the center of the ship. Ranging from 250 to 650 square feet, all of the spacious staterooms feature full-size bathrooms, roomy closets, and private balconies where you can enjoy daily breakfast room service. American Melody also offers the Ellipse Café for casual dining, an option that has been very popular with the guests.
  • Maiden Voyage:
    2021
  • Registry:
    United States
  • Passenger Capacity:
    175
  • Number of Staterooms:
    91
  • Number of Suites:
    16
  • Dining / Restaurants:
    2
  • Bars / Lounges:
    4
  • Fitness Center:
    Yes

Ship Information

Explore Your Cruise Ship

  • Dining

  • Bar & Lounges

  • Onboard Activities

  • Outdoor Activities

  • Wellness

The colorfully painted beach houses of Slovenia as seen from a cave
Don't Miss Out on Any Trip Enhancing Shore Excursions!
Immerse yourself in local culture with authentic cooking classes, traditional dance lessons, and unforgettable visits to historical landmarks during your cruise shore excursions.
A beautiful wooden foyer with luxury seating and shelves filled with fine items
Extend Your Trip with Immersive Pre-Cruise or Post-Cruise Stays
Enjoy the local culture and savor delicious cuisine with pre-cruise or post-cruise stays, ensuring a seamless transition between your land and sea adventures.