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22 Nights - New Orleans To St. Paul

22-night Complete Mississippi River Cruise

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American Serenade
cruise info

22 Nights - New Orleans To St. Paul

  • American Cruise Lines: American Serenade
  • |
  • June 12, 2026

itinerary

  1. Day 1
    New Orleans
    | Fri Jun 12, 2026
  2. Day 2
    Mississippi River Cruising
    | Sat Jun 13, 2026
  3. Day 3
    Oak Alley Plantation
    | Sun Jun 14, 2026
  4. Day 4
    Houmas House
    | Mon Jun 15, 2026
  5. Day 5
    Baton Rouge
    | Tue Jun 16, 2026
  6. Day 6
    St. Francisville
    | Wed Jun 17, 2026
  7. Day 7
    Natchez
    | Thu Jun 18, 2026
  8. Day 8
    Vicksburg
    | Fri Jun 19, 2026
  9. Day 9
    Greenville
    | Sat Jun 20, 2026
  10. Day 10
    Tunica
    | Sun Jun 21, 2026
  11. Day 11
    Memphis
    | Mon Jun 22, 2026
  12. Day 12
    Cape Girardeau
    | Tue Jun 23, 2026
  13. Day 13
    Mississippi River Cruising
    | Wed Jun 24, 2026
  14. Day 14
    St. Louis
    | Thu Jun 25, 2026
  15. Day 15
    Mississippi River Cruising
    | Fri Jun 26, 2026
  16. Day 16
    Hannibal
    | Sat Jun 27, 2026
  17. Day 17
    Mississippi River Cruising
    | Sun Jun 28, 2026
  18. Day 18
    Muscatine
    | Mon Jun 29, 2026
  19. Day 19
    Dubuque
    | Tue Jun 30, 2026
  20. Day 20
    Mississippi River Cruising
    | Wed Jul 1, 2026
  21. Day 21
    Winona
    | Thu Jul 2, 2026
  22. Day 22
    Red Wing
    | Fri Jul 3, 2026
  23. Day 23
    St. Paul
    | Sat Jul 4, 2026
Sailing Features
  • 22 Nights
  • Jun 12, 2026 / Jul 4, 2026
  • New Orleans
  • St. Paul
  • American Serenade
  • 23 Land Tours
Bonus Offers
Exclusive Amenities Available:
  • $100 per Couple Shipboard Credit

American Cruise Lines Expert Advisors

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Roni Palacios

(520) 428-7714
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Whitney Adams

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Vicki Keune

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American Serenade cruise ship

American Cruise Lines:   American Serenade

American Serenade won Cruise Critic’s Editors’ Picks Award for Best New River Cruise Ship of the Year recently, the first time an American ship has received this prestigious award. Introduces an updated modern interior design, integrating an elegant and refined aesthetic with tradition for the spacious comfort found aboard all of ships Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.
  • Maiden Voyage:
    2023
  • Passenger Capacity:
    175
  • Number of Staterooms:
    91
  • Number of Suites:
    16
  • Wheelchair Accessible:
    Yes
The colorfully painted beach houses of Slovenia as seen from a cave
Don't Miss Out on Any Trip Enhancing Shore Excursions!
Immerse yourself in local culture with authentic cooking classes, traditional dance lessons, and unforgettable visits to historical landmarks during your cruise shore excursions.
A beautiful wooden foyer with luxury seating and shelves filled with fine items
Extend Your Trip with Immersive Pre-Cruise or Post-Cruise Stays
Enjoy the local culture and savor delicious cuisine with pre-cruise or post-cruise stays, ensuring a seamless transition between your land and sea adventures.