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15 Nights - St. Paul To New Orleans

15-night Grand Heartland Cruise

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American Serenade
cruise info

15 Nights - St. Paul To New Orleans

  • American Cruise Lines: American Serenade
  • |
  • September 25, 2026

itinerary

  1. Day 1
    St. Paul
    | Fri Sep 25, 2026
  2. Day 2
    Mississippi River Cruising
    | Sat Sep 26, 2026
  3. Day 3
    La Crosse
    | Sun Sep 27, 2026
  4. Day 4
    Dubuque
    | Mon Sep 28, 2026
  5. Day 5
    Davenport
    | Tue Sep 29, 2026
  6. Day 6
    At Sea
    | Wed Sep 30, 2026
  7. Day 7
    Hannibal
    | Thu Oct 1, 2026
  8. Day 8
    At Sea
    | Fri Oct 2, 2026
  9. Day 9
    St. Louis
    | Sat Oct 3, 2026
  10. Day 10
    Memphis
    | Sun Oct 4, 2026
  11. Day 11
    Tunica
    | Mon Oct 5, 2026
  12. Day 12
    At Sea
    | Tue Oct 6, 2026
  13. Day 13
    Vicksburg
    | Wed Oct 7, 2026
  14. Day 14
    Natchez
    | Thu Oct 8, 2026
  15. Day 15
    Baton Rouge
    | Fri Oct 9, 2026
  16. Day 16
    New Orleans
    | Sat Oct 10, 2026
Sailing Features
  • 15 Nights
  • Sep 25, 2026 / Oct 10, 2026
  • St. Paul
  • New Orleans
  • American Serenade
  • 16 Land Tours
Bonus Offers
Exclusive Amenities Available:
  • $100 per Couple Shipboard Credit

American Cruise Lines Expert Advisors

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Roni Palacios

(520) 428-7714
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Mary Beth Preston

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Thea Lawrence

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American Serenade cruise ship

American Cruise Lines:   American Serenade

American Serenade won Cruise Critic’s Editors’ Picks Award for Best New River Cruise Ship of the Year recently, the first time an American ship has received this prestigious award. Introduces an updated modern interior design, integrating an elegant and refined aesthetic with tradition for the spacious comfort found aboard all of ships Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.
  • Maiden Voyage:
    2023
  • Passenger Capacity:
    175
  • Number of Staterooms:
    91
  • Number of Suites:
    16
  • Wheelchair Accessible:
    Yes

Ship Information

Explore Your Cruise Ship
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Don't Miss Out on Any Trip Enhancing Shore Excursions!
Immerse yourself in local culture with authentic cooking classes, traditional dance lessons, and unforgettable visits to historical landmarks during your cruise shore excursions.
A beautiful wooden foyer with luxury seating and shelves filled with fine items
Extend Your Trip with Immersive Pre-Cruise or Post-Cruise Stays
Enjoy the local culture and savor delicious cuisine with pre-cruise or post-cruise stays, ensuring a seamless transition between your land and sea adventures.