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Savings on the Mississippi with American Cruise Lines
Discover the Mississippi with American Cruise Line!
EXPIRESAug 31, 2025
Details & Inclusions
Discover the Mississippi with American Cruise Line
From northern Minnesota to its mouth at the Gulf of Mexico, the Mississippi River offers a uniquely American cruise experience. With more than 50 years’ experience and a fleet of 5 ships ranging from steamboat-style paddlewheelers to the newest modern luxury riverboats, American Cruise Lines is the leading operator of Mississippi River cruises.
Contact our American Cruise Lines experts at 1-800-439-7963 and ask our experts how to get extra perks on the new itineraries like shipboard credit & more!Itineraries
- Extra Amenities Included8-night Upper Mississippi River CruiseSt. Louis -> St. Paul
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Jul 11, 2025 - Extra Amenities Included8-night The Tennessee Rivers CruiseNashville -> Chattanooga
Cruise Line
American Cruise LinesCruise Ship
American SymphonyDeparts
Jul 8, 2025 - Extra Amenities Included8-night Music Cities CruiseMemphis -> Nashville
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Jul 22, 2025 - Extra Amenities Included8-night Upper Mississippi River CruiseSt. Louis -> St. Paul
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Jul 25, 2025 - Extra Amenities Included15-night Grand Ohio River CruisePittsburgh -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Aug 15, 2025 - Extra Amenities Included8-night The Tennessee Rivers CruiseChattanooga -> Nashville
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Aug 5, 2025 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Aug 19, 2025 - Extra Amenities Included8-night Upper Mississippi River CruiseSt. Paul -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Sep 5, 2025 - Extra Amenities Included15-night Grand Heartland CruiseSt. Paul -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
Sep 12, 2025 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
Oct 3, 2025 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Oct 10, 2025 - Extra Amenities Included15-night Grand Heartland CruiseSt. Paul -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Oct 17, 2025 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
Oct 28, 2025 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SymphonyDeparts
Nov 4, 2025 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Nov 21, 2025 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Dec 10, 2025 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Feb 13, 2026 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Feb 27, 2026 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Mar 12, 2026 - Extra Amenities Included11-night Mississippi Explorer CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Mar 18, 2026 - Extra Amenities Included11-night Mississippi Explorer CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Mar 28, 2026 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Apr 10, 2026 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
Apr 21, 2026 - Extra Amenities Included8-night The Tennessee Rivers CruiseNashville -> Chattanooga
Cruise Line
American Cruise LinesCruise Ship
American SymphonyDeparts
Apr 28, 2026 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
May 15, 2026 - Extra Amenities Included8-night Upper Mississippi River CruiseSt. Paul -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Jul 31, 2026 - Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Jul 14, 2026 - Extra Amenities Included11-night Mississippi River Gateway CruiseNew Orleans -> Louisville
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
Jun 22, 2026 - Extra Amenities Included8-night Music Cities CruiseMemphis -> Nashville
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Jul 21, 2026 - Extra Amenities Included11-night Great Smoky Mountains National Park Cruise/Land PackageNashville -> Knoxville
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Sep 8, 2026 - Extra Amenities Included8-night The Tennessee Rivers CruiseNashville -> Chattanooga
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Sep 15, 2026 - Extra Amenities Included15-night Grand Heartland CruiseSt. Paul -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Sep 25, 2026 - Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
Sep 25, 2026 - Extra Amenities Included8-night Upper Mississippi River CruiseSt. Paul -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Sep 11, 2026 - Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Nov 3, 2026 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Feb 18, 2027 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SymphonyDeparts
Mar 3, 2027 - Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
May 4, 2027 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
May 20, 2027 - Extra Amenities Included22-night Complete Mississippi River CruiseNew Orleans -> St. Paul
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
May 21, 2027 - Extra Amenities Included8-night Upper Mississippi River CruiseSt. Paul -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Jul 2, 2027 - Extra Amenities Included8-night The Tennessee Rivers CruiseChattanooga -> Nashville
Cruise Line
American Cruise LinesCruise Ship
American Splendor (formerly America®)Departs
Aug 3, 2027 - Extra Amenities Included15-night Grand Ohio River CruisePittsburgh -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
Aug 26, 2027 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American Heritage (formerly Queen of the Mississippi)Departs
Oct 8, 2027 - Extra Amenities Included15-night Grand Heartland CruiseSt. Paul -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Oct 15, 2027 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Oct 28, 2027 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Nov 16, 2027 - Extra Amenities Included7-night Historic Mississippi River CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Dec 2, 2027 - Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Dec 21, 2027
Terms & Conditions
Offer availability can change or be withdrawn at any time. Offers are based on double occupancy. Pricing will already reflect promotional savings. No further savings will apply. Savings amount is per stateroom, varies by departure, and is based on limited availability. Ship, itinerary, savings, and schedules are subject to change. Travel advisors: This offer does not apply to Groups. Promotion is subject to availability, capacity controlled, and may be changed/withdrawn at any time without notice. Other restrictions may apply. Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time booking and may be pulled without notice. We reserve the right to correct errors. Information and pricing is subject to change without notice. While we do our very best to ensure that information and pricing appearing in this website is complete and accurate, we cannot be responsible for incomplete and inaccurate representations, which may or may not be under our control. In the event of a pricing error, misrepresentation or omission, we reserve the right to adjust the pricing or make any other corrections. Other restrictions may apply. Contact Bon Voyage Travel for complete terms and conditions.