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Savings on the Mississippi with American Cruise Lines

Save up to $1,500 + Air Savings on select Mississippi River sailings!

EXPIRESApr 30, 2025

Details & Inclusions

Save up to $1,500+ Air Savings on select Mississippi River sailings!

From northern Minnesota to its mouth at the Gulf of Mexico, the Mississippi River offers a uniquely American cruise experience. With more than 50 years’ experience and a fleet of 5 ships ranging from steamboat-style paddlewheelers to the newest modern luxury riverboats, American Cruise Lines is the leading operator of Mississippi River cruises.

For a limited time, you can enjoy $1,500 Savings + Complimentary Airfare on select Mississippi River sailings! Plus, ask us how you can also receive air savings! Contact our American Cruise Lines experts at 1-800-439-7963 before this offer ends!

Itineraries

  1. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Apr 29, 2025
  2. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    May 4, 2025
  3. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    May 16, 2025
  4. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    May 27, 2025
  5. Extra Amenities Included
    8-night Upper Mississippi River Cruise
    St. Louis -> St. Paul

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Jul 11, 2025
  6. Extra Amenities Included
    8-night The Tennessee Rivers Cruise
    Nashville -> Chattanooga

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Jul 8, 2025
  7. Extra Amenities Included
    8-night Music Cities Cruise
    Memphis -> Nashville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Jul 22, 2025
  8. Extra Amenities Included
    8-night Upper Mississippi River Cruise
    St. Louis -> St. Paul

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Jul 25, 2025
  9. Extra Amenities Included
    15-night Grand Ohio River Cruise
    Pittsburgh -> St. Louis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Aug 15, 2025
  10. Extra Amenities Included
    8-night The Tennessee Rivers Cruise
    Chattanooga -> Nashville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Aug 5, 2025
  11. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Aug 19, 2025
  12. Extra Amenities Included
    8-night Upper Mississippi River
    St. Paul -> St. Louis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Sep 5, 2025
  13. Extra Amenities Included
    15-night Grand Heartland Cruise
    St. Paul -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Sep 12, 2025
  14. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Oct 3, 2025
  15. Extra Amenities Included
    8-night Music Cities Cruise
    Memphis -> Nashville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Sep 30, 2025
  16. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Oct 10, 2025
  17. Extra Amenities Included
    15-night Grand Heartland Cruise
    St. Paul -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Oct 17, 2025
  18. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Oct 28, 2025
  19. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Nov 4, 2025
  20. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Nov 21, 2025
  21. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Dec 10, 2025
  22. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Feb 13, 2026
  23. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Feb 27, 2026
  24. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Mar 12, 2026
  25. Extra Amenities Included
    11-night Mississippi Explorer Cruise
    New Orleans -> Memphis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Mar 18, 2026
  26. Extra Amenities Included
    11-night Mississippi Explorer Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Mar 28, 2026
  27. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Apr 10, 2026
  28. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Apr 21, 2026
  29. Extra Amenities Included
    8-night The Tennessee Rivers Cruise
    Nashville -> Chattanooga

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Apr 28, 2026
  30. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    May 15, 2026
  31. Extra Amenities Included
    8-night Upper Mississippi River Cruise
    St. Paul -> St. Louis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Aug 1, 2026
  32. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    New Orleans -> Memphis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Jul 14, 2026
  33. Extra Amenities Included
    11-night Mississippi River Gateway Cruise
    New Orleans -> Louisville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Jun 22, 2026
  34. Extra Amenities Included
    8-night Music Cities Cruise
    Memphis -> Nashville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Jul 21, 2026
  35. Extra Amenities Included
    11-night Great Smoky Mountains National Park Cruise/Land Package
    Nashville -> Knoxville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Sep 8, 2026
  36. Extra Amenities Included
    8-night The Tennessee Rivers Cruise
    Nashville -> Chattanooga

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Sep 15, 2026
  37. Extra Amenities Included
    15-night Grand Heartland Cruise
    St. Paul -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Sep 25, 2026
  38. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    New Orleans -> Memphis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Sep 25, 2026
  39. Extra Amenities Included
    8-night Upper Mississippi River Cruise
    St. Paul -> St. Louis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Sep 12, 2026
  40. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Oct 27, 2026
  41. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    New Orleans -> Memphis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Nov 3, 2026
  42. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Feb 19, 2027
  43. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Symphony

    Departs

    Mar 3, 2027
  44. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    New Orleans -> Memphis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    May 4, 2027
  45. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    May 21, 2027
  46. Extra Amenities Included
    22-night Complete Mississippi River Cruise
    New Orleans -> St. Paul

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    May 22, 2027
  47. Extra Amenities Included
    8-night Upper Mississippi River Cruise
    St. Paul -> St. Louis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Jul 3, 2027
  48. Extra Amenities Included
    8-night The Tennessee Rivers Cruise
    Chattanooga -> Nashville

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Splendor (formerly America®)

    Departs

    Aug 3, 2027
  49. Extra Amenities Included
    15-night Grand Ohio River Cruise
    Pittsburgh -> St. Louis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Aug 27, 2027
  50. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Heritage (formerly Queen of the Mississippi)

    Departs

    Oct 9, 2027
  51. Extra Amenities Included
    15-night Grand Heartland Cruise
    St. Paul -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Oct 16, 2027
  52. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Oct 29, 2027
  53. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    Memphis -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Serenade

    Departs

    Nov 17, 2027
  54. Extra Amenities Included
    7-night Historic Mississippi River Cruise
    New Orleans -> New Orleans

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Dec 3, 2027
  55. Extra Amenities Included
    8-night Lower Mississippi River Cruise
    New Orleans -> Memphis

    Cruise Line

    American Cruise Lines

    Cruise Ship

    American Melody

    Departs

    Dec 21, 2027

Terms & Conditions

Offer availability can change or be withdrawn at any time. Offers are based on double occupancy. Pricing will already reflect promotional savings. No further savings will apply. Savings amount is per stateroom, varies by departure, and is based on limited availability. Ship, itinerary, savings, and schedules are subject to change. Travel advisors: This offer does not apply to Groups. Promotion is subject to availability, capacity controlled, and may be changed/withdrawn at any time without notice. Other restrictions may apply. Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time booking and may be pulled without notice. We reserve the right to correct errors. Information and pricing is subject to change without notice. While we do our very best to ensure that information and pricing appearing in this website is complete and accurate, we cannot be responsible for incomplete and inaccurate representations, which may or may not be under our control. In the event of a pricing error, misrepresentation or omission, we reserve the right to adjust the pricing or make any other corrections. Other restrictions may apply. Contact Bon Voyage Travel for complete terms and conditions.