Voyage Beyond Horizons
Discover the majestic beauty of the deep blue sea on a luxury cruise.
Embrace Aquatic Tranquility
Savor the charm of a river journey, where luxury meets nature's tranquility.
Journey Beyond the Ordinary
Step into a world of breathtaking landscapes and rich cultures with our curated land tours.
Save More on Mississippi River Cruises with American Cruise Lines
Save More on Mississippi River Cruises with American Cruise Lines — Exclusive Offers & Added Perks
Details & Inclusions
Itineraries
Promotion Sailings
- Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American SplendorDeparts
Jul 14, 2026 - Extra Amenities Included8-night Music Cities CruiseMemphis -> Nashville
Cruise Line
American Cruise LinesCruise Ship
American SplendorDeparts
Jul 21, 2026 - Extra Amenities Included8-night Upper Mississippi River CruiseSt. Paul -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Jul 31, 2026 - Extra Amenities Included11-night Smoky Mountains National Park Cruise/Land PackageNashville -> Knoxville
Cruise Line
American Cruise LinesCruise Ship
American SplendorDeparts
Sep 8, 2026 - Extra Amenities Included8-night Upper Mississippi River CruiseSt. Paul -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Sep 11, 2026 - Extra Amenities Included8-night Tennessee Rivers CruiseNashville -> Chattanooga
Cruise Line
American Cruise LinesCruise Ship
American SplendorDeparts
Sep 15, 2026 - Extra Amenities Included15-night Grand Heartland CruiseSt. Paul -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Sep 25, 2026 - Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American HeritageDeparts
Sep 25, 2026 - Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American SplendorDeparts
Nov 3, 2026 - Extra Amenities Included8-night Lower Mississippi River CruiseNew Orleans -> Memphis
Cruise Line
American Cruise LinesCruise Ship
American SplendorDeparts
May 4, 2027 - Extra Amenities Included7-night Highlights of the Mississippi CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American HeritageDeparts
May 15, 2027 - Extra Amenities Included8-night Upper Mississippi River CruiseSt. Paul -> St. Louis
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Jul 2, 2027 - Extra Amenities Included8-night Tennessee Rivers CruiseChattanooga -> Nashville
Cruise Line
American Cruise LinesCruise Ship
American SplendorDeparts
Aug 3, 2027 - Extra Amenities Included15-night Grand Heartland CruiseSt. Paul -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American MelodyDeparts
Oct 15, 2027 - Extra Amenities Included7-night Highlights of the Mississippi CruiseNew Orleans -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Oct 28, 2027 - Extra Amenities Included8-night Lower Mississippi River CruiseMemphis -> New Orleans
Cruise Line
American Cruise LinesCruise Ship
American SerenadeDeparts
Nov 16, 2027
Terms & Conditions
Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time of booking and may be pulled without notice. Pricing may already reflect savings and no further savings will apply. Savings is off cruise fare only; all other charges, including but not limited to, cruise taxes, fees and port expenses are additional and apply to all guests. Information and pricing is subject to change without notice. Not all promotions/sales are combinable. Other restrictions apply. Contact us for details.